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| 신부전증과 폐에 Pseudolymphoma를 동반한 원발성 Sjogren 증후군 : Cyclophosphamide와 Prednisolone에 의한 성공적인 치료 (Primary Sjogren`s Syndrome Presenting with a Huge Pulmonary Mass and Acute Renal Insufficieney) |
| 강민규(Min Gyu Kang),구영선(Young Sun Goo),황평주(Pyung Joo Hwang),김종학(Jong Hak Kim),나기량(Gee Ryang Na),서광선(Gwang Sun Seo),이강욱(Kang Wook Lee),신영태(Young Tae Shin) |
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| Abstract |
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Sjogren's syndrome(SS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of the lacrimal and salivary glands, which result in dry eye and dry mouth. Systemic involvement including the lungs, gastrointestinal tract, kidneys, endocrine glands, skin, or nervous system has been reported. Pulmonary abnormalities in SS are lymphoid interstitial infiltration, chronic bronchitis, pulmonary fibrosis and pleurisy. Pulmonary pseudolymphoma associated with acute renal insufficiency is very rare. Recently, we experienced a patient with SS presenting with a huge pulmonary mass in the left upper lobe and acute renal failure. Pulmonary pseudolymphoma and renal functional impairment were completely reversed after a six month treatment with oral prednisolon(lmg/kg, body weight) and monthly cyclophosphamide pulse therapy (12mg/kg, I.V.). There was no evidence of disease recurrence for 16 months after discontinuation of prednisolone therapy. |
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