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| Hemoperfusion과 Methylene Blue로 치료한 Pendipronil 중독 1예 (A Case of Pendipronil Poisoning Treated by Hemoperfusion and Methylene Blue) |
| 정병곤(Byung Gon Jung),김지겸(Jee Gyum Kim),백영권(Young Gwon Baek),박성호(Sung Ho Park),김경욱(Gyung Wook Kim) |
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| Abstract |
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Pendipronil overdose is uncommon in Korea. Pendipronil is a selective herbicide used to control most annual grasses and certain broadleaf weeds in field corn, potatoes, rice, etc. and is the substance including pendimethalin and propanil. Pendimethalin is slightly to practically nontoxic by ingestion but may he mildly to moderately irritating to the linings of the mouth, nose, throat, and lungs. Propanil toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. For the treatment of methemoglobinemia, gastric lavage, activated charcoal, methylene blue and exchange transfusion should be used. We experienced a case of acute massive Pendipronil intoxication in 31 years old woman due to voluntary ingestion of 48g of this drug as a suicide attempt. A moderate methemoglobinemia developed, accompanied by drowsy mental status, nausea, vomiting, headache, intensive cyanosis. The patient recovered completely after intravenous methylene blue injection and cellulose coated hemoperfusion charcoal (Adsorba 300C) and conservative treatment. |
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