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| 항사구체기저막 항체 및 c-ANCA 양성인 급속 진행성 사구체 신염 1예 (A Case of Anti-Glomerular Basement Membrane Antibody Associated Crescentic Glomerulonephritis with Positive Antineutrophilic Cytoplasmic Antibody) |
| 이규환 ( Kyu Hwan Lee ) , 김대영 ( Dae Young Kim ) , 정재성 ( Jae Sung Chung ) , 김강희 ( Kang Hee Kim ) , 공진민 ( Jin Min Kong ) , 이동렬 ( Dong Ryoul Lee ) , 조진훈 ( Jin Hoon Cho ) , 김병창 ( Sun Hee Yun ) , 윤선희 ( Beung Chang Kim ) |
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| Abstract |
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A 63-year-old woman presented to the hospital with gross hematuria and acute renal failure. Kidney function deteriorated rapidly and progressively. A renal biopsy revealed segmental or circumferential crescents associated with linear deposits of immunoglobulin G, typical of anti-glomerular basement membrane disease. Both c-ANCA and anti-GBM antibody were detected in serum. She was treated with hemodialysis, plasmapheresis, high dose steroid and cyclophosphamide. However, she died 7 weeks after treatment because of pneumonia, without recovery of renal function. Serologic positivity of both ANCA and anti-GBM antibody are becoming more frequently recognized in rapidly progressive glomerulonephritis. The influence of c-ANCA on the clinical course of anti-GBM glomerulonephritis remains to be determined. |
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