|
| 신장질환에서의 Insulin - like Growth Factor Binding Pretein 의 특징 |
| 이광래 , 이병근 , 김정수 , 이대열 |
|
|
| Abstract |
|
Insulin-like growth factors, IGF- I and IGF-II, are protein that promote cellular growth and differentiation of various organs including the kidney. Each peptide interacts with high-affinity receptors and also has high affinity for a family of insulin-like growth factor bind- ing proteins (IGFBPs). Altered serum IGFBP patterns in acute and chronic renal failure have been described. In this study, We have evaluated serum IGFBP profiles in various renal diseases (n=21), by using western ligand blot. Nephrotic syndrome and renal failure patients showed decreased intact serum IGFBP-3 and increased serum IGFBP-2. Low molecular weight from of IGFBP -3 was found only in chronic renal failure but not in nephrotic syndrome. To evaluate altered IGFBP profi@les, We performed IGFBP-3 protease assay with sera from renal diseases. Control serum and sera from all renal diseases did not showed protease activity. Although the exact role of alteration of serum IGFBPs pattern was not established, this alteration may play a rol in the modulation of IGFs action on kidney. |
|
PDF Links
Download Citation
