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| 카드뮴 신 손상에 관한 전자현미경적 연구 |
| 박관규 |
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| Abstract |
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To evaluate the influence of hemodialysis and contin- uous ambulatory peritoneal dialysis (CAPD) on the elimination of carumonam, pharmacokinetic studies were performed in 14 CRF patients undergoing intermit- tent hemodialysis or CAPD after a single intravenous dose of 1 g. Carumonam concentrations in biological fluid were measured by reverse phase high perfomance liquid chromatography. In patients undergoing intermittent hemodialysis, car- umonam plasma half-life of 14.36± 5.18 hr was shor- tened to 2.25±0.54 hr during hemodialysis. Hemo- dialysis increased the total body clearance of car- umonam from 14.0 to 82,0ml/min, and the amount of carumonam recovered into dialysate over 4 or 5 hrs ranged from 363 to 895 mg (average: 520,6±163.9 mg). In patients undergoing CAPD, the volume of distribution and plasma half-life of carumonam were 0.26±0,091/ kg and 10.5±4.36 hr, respectively. The time-averaged net clearance of peritoneal dialysis was negligible (3. 6±1,7 ml/min) compared with hemodialysis clearance. Patient undergoing hemodialysis should receive a sup- plemental dose equal to half of their maintenance dose immediately after each dialysis session. |
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