Korean Journal of Nephrology 1993;12(4):579-587.
소아 신증후군에서의 혈전증
구자욱 , 박혜원 , 하태선 , 하일수 , 정해일 , 최용
Abstract
We reviewed 10 nephrotic children with thromboem- bolic complications who were admitted to the Depart- ment of Pediatrics, Seoul National University Childrens' Hospital between May 1984 and march 1993 and the following results were obtained. 1) The patterns of thrombosis were pulmonary throm- boebolism (4 cases including 1 pulmonary artery throm- bosis), cerebral infarction (2 cases), renal vein throm- bosis (2 cases), femoral artery thrombosis (1 case), radial artery thrombosis (1 case), and femoral vein with deep vein thrombosis (1 case). Among these cases, the radial artery throbmosis was accompanied with pul- monary thromboembolism 2) The possible factors associated with thrombosis were as follows: iatrogenic factors (accidental femoral puncture and radial artery cannulation), steroid, diuretic therapy, hypovolvemic episode, sepsis and stasis. 3) Patients with only pulmonary thromboembolism or renal vein thrombosis improved considerably under the conservative treatment with systemic heparinization and anticoagulants. One patient with femoral artery thrombosis recovered completely with emergency thrombectomy, systemic heparinization and anticoagulant. Two patients were expired with massive pulmonary artery thrombosis and radial artery thrombosis. Unexplained pulmonary symptoms, decreased breathing sound and pneumonic infiltration on the chest X-ray during relapsing nephrotic syndrome should prompt further investigations to rule out Femoral artery punctures, or arterial cannulation of the extremities in patients with the nephrotic syndrome should be avoided
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