Korean Journal of Nephrology 1991;10(1):32-43.

최근 3년간의 요로 감염증의 주요 원인균과 항생제 감수성에 관한 연구

전노원 , 채동완 , 이영천 , 오하영 , 류지소 , 이영

Abstract

A bacteriologic study in patient with urinary tract infection was done for identification of causative organ- isms and their antibitotic susceptibility at Hangang Sacred Heart Hospital from 1987 to 1989 The following results were obtained; 1) Positive urine culture samples in 1278 specimens were analyzed and 731 & 547 specimens were observed each in outpatients (community acquired) & inpatients (hospital acquired). 2) The ratio of male to female was 1:3.9 with com- munity acquired urinary tract infection and 1:0.7 with hospital acquired urinary tract infection. 3) In age distribution, the majority of female patients with community acquired infection were seen in 20-49 years (52.8%). 4) The predisposing factors of hospital acquired urinary tract infection were indwelling Foley catheter (92%), cystostomy (2%), cystoscopy (2%), retrograde pyelography (1%), and intermittent catheterization (1%) in that order. The associated diseases of hospital acquired urinary tract infection were cerebrovascular accident (42%), bum (18%), diabetes mellitus (14%), and traumatic urethral injury (6%) in that order. 5) The common pathogens of hospital acquired urinary tract infection were Pseudomonas aeruginosa (24.2%), E.coli (14.6%), coagulase negative Staphylococ- ci (13.6%), Klebsiella spp. (10%), Enterobacter spp. (9.7%), and Enterococci (8.8%) in that order. The common pathogens of community acquired urinary tract infection were E.coli (44.9%) and coagulase negative Staphylococci (24.8%) in that order. Coagulase negative Staphylococci were markedly in- creased in frequency than previous reports. 6) The antibiotic susceptibility of hospital acquired pathogens were as follows: Pseudomonas aeruginosa was 58.2% to amikacin and less than 50% to other antibiotics. E.coli was 82.5% to amikacin and less than 50% to other antibiotics. E.coli was 82.5% to amikacin and less than 50% to other antibiotics. Coagulase nega- tive Staphylococci were 61.2% to cephalothin and less than 50% to other antibiotics. 7) The antibiotic susceptibility of community acquired pathogens wer as follows: E.coli was 96% to amikacin, 86% to tobramycin, 86% to gentamicin, 66% to cephalothin, and 55% to kanamycin. Coagulase nega- tive Staphylococci were 91% to cephalothin, 65% to gentamicin, and less than 55% to other antibiotics. 8) In 1987 and 1988, the susceptibility to ofloxacin in patient with gram negative rods was 96%.