|
| 미세변화 신증후군의 발병기전에 있어서 IgA - Receptor의 역할과 새로운 면역치료법의 개발에 관한 연구 |
| 조병수 , 안창일 , 이충은 , 변광호 |
|
|
| Abstract |
|
Minimal change nephrotic syndrome (MCNS) has been often associated with elevated IgE levels and refer- red to involve immune dysfunction. We investigated the role of interleukin-4 (IL-4) in the pathogenesis of MCNS through the regulation of membrane FceR II, low af- finity receptor for IgE, expressed on B-cells. A signi- ficantly higher expression of membrane FceR II was found on fresh B-cells of MCNS (N =18) than on those of normals, as analyzed by fluorescence activated cell scanner by double antibody staining with anti Leu 16 (pan B marker)-FITC and anti Leu 20 (FceR II)- phycoerythrin. Sera from these patients also demon- strated increased IL-4 activity as compared with those of normal subjects. We observed that nephrotie T-cells has a greater ability (up to 9 fold) than aormal cells to produce IL-4 as assayed by B-cell proliferation and FceR II expression. As in the case of normal B-cells, ne- phrotic B-cells were likely responsive to IL-4 (5-100 U/ ml) to effectively induce FceR II expression (up to 6 fold). These results suggest that MCNS may be a T-cell disorder involving abnormal production of IL-4 and that the counter-regulation of FceR II by IL-4 may play a role in pathogenesis of MCNS. |
|
PDF Links
Download Citation
