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| 소아 신증후군 환야에서 Cyclosporine A의 치료 효과 |
| 손은경 , 조병수 |
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| Abstract |
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T-cell dysfunction was postulated in the pathogenesis of idiopathic nephrotic syndrome. Cyclosporine A has highly selective immune suppressive action by inhibition of the production of interleukin 2 by helper T-cells. We treated 16 steroid-resistant or steroid dependent nephrotic syndrome patients with cyclosporin A for 8 weeks in combination with alternate PDL therapy. The results were as follows: 1) All patients responded to cyclosporine A treat-ment. Response has been maintained in 14 patients and relapse was occurred in 2 patients after discontinuation of cycloporine A on follow up study. 2) Severe side effects of long term PDL therapy, eg, osteoporosis or marked Cushingoid appearance, were improved by decreased dosage of steroid, which was possible with combining cyclosporine A therapy. 3) The most common side effect of cyclosporine was hypertrichosis, which was found in all patients but it was transient. Hypertension, facial flushing and infec- tion (moniliasis) were observed but nephrotoxity wasnt. Thus long term follow up studies of cyclosporine A in childhood nephrotic syndrome patients remain to be evaluated but short term follow up results of cyclospor- ine A in the treatment of frequent relapsing or steroid resistant nephrotic syndrome were effective without significant side effect. |
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