Korean Journal of Nephrology 1987;6(1):147-152.

신증후군 환자의 고지혈증에 있어서 Procetofen ( Lipanthyl ) 의 치료 효과

문희식 , 김형준 , 박용선 , 강영준

Abstract

It is well documented that hyperlipidemia was com- mon feature of the nephrotic syndrome. There has been considerable debate about whether the hyperlipidemia in such patients leads to an increased risk of atheros- clerotic coronary heart disease and whether these patients require treatment to lower the level of plasma lipids. We studied the plasma lipids level including total cholesterol, triglyceride and HDL cholesterol as well as relation among total cholesterol, triglyceride, total protein and plasma albumin concentration in 15 adult patients with uncomplicated nephrotic syndrome before and after treatment of Procetofen. The following results were obtained: 1) The total cholesterol and triglyceride concentra- tions were significantly decreased after treatment as compared with the concentrations before treatement (P<0.01, P<0.05), while the HDL cholesterol was signif- icantly increased after treatment (P<0.05). 2) Total plasma protein and albumin concentrations were significantly increased after treatment (P<0.05). 3) A significant inverse relation was found between the total plasma cholesterol concentration and both total plasma protein and albumin concentration (before; r= - 0.69 vs - 0,75, after; r= - 0.71 vs- 0.78), but not significant relation among triglyceride and both total plasma protein and albumin concentrations (before; r= - 0.30 vs - 0.35, after; r= 0.45 vs- 0.45).