A Case of Asymptomatic Disseminated Cryptococcosis in a Renal Transplant Patient

Korean Journal of Nephrology 2010;29(2):310-314.

Ji-Min Jeon, M.D.1, Joon-Suk Oh, M.D.1, Sung-Min Kim, M.D.1, Young-Ki Son, M.D.1, Yong-Ki Park, M.D.1, Yong-Hun Sin, M.D.1, Joong-Kyung Kim, M.D.1 and Il Seon Lee, M.D.2

Division of Nephrology¹
Department of Internal Medicine, Department of Pathology²
Bong Seng Memorial Hospital, Busan, Korea

증례 : 신이식 환자에서 발생한 무증상 파종성 크립토콕쿠스증 1예

전지민1, 오준석1, 김성민1, 손영기1, 박용기1, 신용훈1, 김중경1, 이일선2

김원묵 기념 봉생병원 내과학교실1 , 병리과2

Abstract

Cryptococcosis is recognized as one of the most important complications in an organ transplant recipient. Cryptococcosis occurs in 2.5-39% of renal transplant recipients. This infection generally presents as symptomatic disseminated disease with an accelerated clinical course, involves multiple sites including the central nervous system, lungs, and skin. And if diagnosis or treatment is delayed, the prognosis is generally poor. The asymptomatic infection is rare and there are no case reports of asymptomatic disseminated cryptococcosis after renal transplantation in Korea. We experienced a case of asymptomatic cryptococcal multi-organ infection detected incidentally in a 51-year-old male received a living related renal transplant 35 months earlier for end-stage renal disease due to diabetic nephropathy. We treated successfully with amphotericin B and fluconazole and hereby report this case with a review of the relevant literature.

Key Words: Cryptococcosis, Fungal infection, Kidney transplantation