IgA Nephropathy Associated with Chronic Urate Nephropathy

Korean Journal of Nephrology 2008;27(2):234-237.

Jin Hee Cho, M.D.1, Su Kyong Yu, M.D.1 , Jung Il Park, M.D.1, Myoung Hee Lee, M.D.1, Nam Kyu Lymm, M.D.1, In Whee Park, M.D.,1, Heungsoo Kim, M.D.1, Hyunee Yim, M.D.2 , Gyu-tae Shin, M.D.1

Departments of Nephrology¹
Pathology2 Ajou University school of Medicine, Suwon, Korea

증례 : IgA 신증에 동반된 만성 고요산성 신증

조진희1, 유수경1, 박정일1, 이명희1, 임남규1, 박인휘1, 김흥수1, 임현이2, 신규태1

아주대학교 의과대학 신장내과학교실1, 병리학교실2

Abstract

IgA nephropathy is the most common primary glomerulonephritis and characterized by deposition of IgA in glomerular mesangial area. Chronic urate nephropathy is characterized by precipitation of uric acid crystals in the collecting ducts and medullary interstitium. We report a case of IgA nephropathy associated with chronic urate nephropathy. A 57 year old man underwent percutaneous renal biopsy for gross hematuria, generalized edema and renal failure. Renal biopsy showed typical findings of IgA nephropathy: increased mesangial matrix, cellular proliferation and positive staining of IgA. In addition, crystalline deposits of uric acid, which is typical of chronic urate nephropathy, were seen in the medullary interstitium.

Key Words: IgA nephropathy, Uric acid, Glomerulonephritis