Patterns in renal diseases diagnosed by kidney biopsy: a single-center experience
Taehoon Yim1,* , Sang-Un Kim1,* , Sangmi Park1 , Jeong-Hoon Lim1 , Hee-Yeon Jung1 , Jang-Hee Cho1 , Chan-Duck Kim1 , Yong-Lim Kim1 , Man-Hoon Han2 , Yong-Jin Kim2 , Ji-Young Choi1 , Sun-Hee Park1
1Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
2Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Correspondence to: Sun-Hee Park
Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Republic of Korea. E-mail: sh-park@knu.ac.kr
Ji-Young Choi
Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu 41404, Republic of Korea. E-mail: jyss1002@hanmail.net
*These authors contributed equally to this study.

Edited by Beom Jin Lim, Yonsei University, Seoul, Republic of Korea
Received: July 21, 2019; Revised: November 19, 2019; Accepted: November 19, 2019; Published online: January 20, 2020.
© The Korean Society of Nephrology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to a lack of studies and limited research resources for this disease in Korea, we investigated renal disease patterns by analyzing data from kidney biopsies performed over 13 years in a university-based teaching hospital in Korea.
Methods: Among 2,053 kidney biopsies performed from 2001 to 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed for histopathologic, demographic, and clinical data as well as laboratory results.
Results: Among the 1,924 studied kidney biopsies, 1,078 were males (56.0%) and the mean age was 37.7 ± 16.5 years. Asymptomatic urinary abnormalities were the most common clinical manifestation (62.5%). Immunoglobulin A nephropathy (IgAN) was the most common primary glomerular disease (37.4%), followed by minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulonephritis and crescentic glomerulonephritis. Secondary glomerular diseases accounted for 10.3% of the total biopsies, with lupus nephritis being the most common (4.6%) followed by Henoch-Schönlein purpura nephritis and diabetic nephropathy. The most common cause of nephrotic syndrome was MCD (42.1%) followed by MN. Among patients seropositive for hepatitis B or C, IgAN (28.3% and 21.4%, respectively) was the most common cause.
Conclusion: IgAN and lupus nephritis were the most common primary and secondary glomerular diseases, respectively. Race, region, and practice patterns may affect renal disease patterns in different cohorts.
Keywords: Biopsy, Glomerulonephritis, Kidney diseases, Nephrotic syndrome


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