Kidney Research and Clinical Practice : eISSN 2211-9140 / pISSN 2211-9132

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Fig. 2. Mechanisms of cholinergic anti-inflammatory pathway activation between vagus nerve stimulation and C1 neuron stimulation.

Subdiaphragmatic vagotomy does not abolish renal protection, indicating that C1 neuron-mediated cholinergic anti-inflammatory pathway (CAP) activation does not occur via a parasympathetic route but via a sympathetic route. The mechanism of CAP activation via C1 neurons (sympathetic) might differ from that via vagus nerve stimulation (parasympathetic). The dotted lines are strongly suggested, though not conclusively proven, pathways.

Ach, acetylcholine; α7nAChR, alpha 7 subunit of the nicotinic acetylcholine receptor; β2AR, β2 adrenergic receptor; DMV, dorsal motor nucleus of the vagus; NE, norepinephrine; SGN, sympathetic ganglionic neuron; SPGN, sympathetic preganglionic neuron; TNF-α, tumor necrosis factor alpha.

Kidney Res Clin Pract 2019;38:282~294
© Kidney Res Clin Pract